Apoptosis Reagents and Kits
Medchemexpress LLC Annexin A1/ANXA1 Mo 1mg
Annexin A1 (ANXA1) Protein, Mouse (His) is a full-length recombinant mouse annexin A1 expressed in Escherichia coli with an N-terminal 6xHis tag, supplied as a lyophilized powder. The protein is >95% pure, has an approximate molecular weight of 40 kDa, and low endotoxin (<1 EU/μg); it is formulated with trehalose for stability and intended for in vitro studies of inflammation, immune signaling, phagocytosis, and chemotaxis.
- Full-length recombinant protein with N-terminal His tag.
- Expressed in Escherichia coli for scalable production.
- Purity greater than 95% by reducing SDS-PAGE.
- Approximately 40 kDa molecular weight.
- Low endotoxin level (<1 EU/μg) suitable for cell-based assays.
- Lyophilized formulation with trehalose for enhanced stability.
- Demonstrated biological activity in suppressing TNF-alpha secretion in RAW264.7 cells.
- Multiple size options available to fit experimental needs.
AdipoGen b-AP15
Chemical. CAS 1009817-63-3. Formula C22H17N3O6. MW 419.4. b-AP15 is a specific deubiquitinase DUB inhibitor. It inhibits ubiquitin-specific-processing protease 14 USP14 and ubiquitin c-terminal hydrolase isozyme L5 UCHL5 UCH37, two 19S regulatory particle proteasome-associated DUBs. It exhibits minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP and BAP1. Has been described to inhibit also the 20S proteasome with an IC50 comparable to that required for inhibiting the 19S regulatory particles. b-AP15 has anticancer properties and blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia. b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells. It induces apoptosis, ER stress and autophagy in several cancer cells. b-AP15 has anti-inflammatory properties inhibiting ERK1/2 and JNK phosphorylation, increasing IkappaBalpha levels and inhibiting NF-kappaB p65.
Cusabio Technology LLC Rat Caspase 3Casp-3 ELISA Kit
This kit detects CASP3 (Caspase-3) in rat serum plasma and tissue homogenates using a quantitative sandwich ELISA method It offers a detection range of 0 312 ng/mL to 20 ng/mL with a sensitivity of 0 078 ng/mL enabling precise measurement of low-abundance targets The assay requires 50-100 L of sample per test and can be completed within 1-5 hours Results are measured at an absorbance wavelength of 450 nm providing reliable data for apoptosis-related research Designed for flexibility it accommodates multiple biological matrices while maintaining robust performance making it suitable for both routine laboratory analysis and experimental studies requiring accurate quantification of Caspase-3 activity
ABclonal Technology Annexin A2 Rabbit pAb
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms.
Abcam Human DAB2 knockout HeLa cell lysate.
Human DAB2 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC Z-VAD(OH)-FMK (Caspase Inhibitor VI) 5mg 161401-82-7
Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Abcam Phalloidin-iFluor 750 Reagent.
Phalloidin-iFluor 750 Reagent.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Caspase-8 Rabbit pAb
This gene encodes a member of the caspase family, crucial for the execution phase of apoptosis. Caspases are synthesized as inactive proenzymes composed of a prodomain, and large and small subunits. Activation requires cleavage at conserved aspartic sites, forming a heterodimeric enzyme. This caspase is activated by Fas and other apoptotic signals and contains a FADD-like death effector domain, suggesting interaction with FADD. It has been detected in insoluble brain fractions of Huntingtons disease patients, indicating a possible role in neurodegeneration. Multiple alternatively spliced transcript variants exist, though not all full-length sequences are known.
Biolegend PE/Cyanine7 Annexin V
PE/Cyanine7 Annexin V Reactivity: All mammalian species; Apps: FC; Size: 25 tests
Apexbio Technology LLC Annexin V-APC/DAPI Apoptosis Kit 200tests
Annexin V-APC/DAPI Apoptosis Kit allow discrimination between cells at various stages of apoptosis and cell death Annexin V is a calcium-dependent phospholipid-binding protein which specifically binds to phosphatidylserine (PS) Under normal conditions PS is located on the inner surface of the cell membrane lipid bilayer but during early apoptosis PS translocates from the inner leaflet to the outer leaflet of the plasma membrane becoming exposed to the extracellular environment By using Annexin V-APC labeling apoptotic cells can be detected easily through flow cytometry or fluorescence microscopy within 15-30 minutes Additionally this kit includes the nuclear stain DAPI which specifically binds to double-stranded DNA to emit blue fluorescence Normally DAPI cannot penetrate intact cell membranes In late apoptotic and dead cells DAPI can cross the compromised membrane to stain the nucleus
Apexbio Technology LLC Annexin V-Biotin Apoptosis Kit, 100 assays
Annexin V is a cellular protein, which plays important roles in the inhibition of the activity of phospholipase A1 and blood coagulation by competing for phosphatidylserine (PS) binding sites with prothrombin. Annexin V has a high affinity to PS and is used as a probe to detect cells that have expressed PS on the cell surface. After initiating apoptosis, cells translocate phosphatidylserine (PS) from the inner face of the plasma membrane to the cell surface soon, which can be easily detected by Annexin V.Annexin V-Biotin Apoptosis Detection Kit uses Biotin-conjugated Annexin V that can easily detect PS on the cell surface after initiating apoptosis. Annexin V-Biotin can be easily detected in combination with conventional dye-staining using any avidin- or streptavidine-dye reagents, such as (strept)avidine-peroxidase, -fluorescein, -alkaline phosphatase (AP), and --gal, etc. Other sizes are also available. Please inqury us for quote.
Abcam Human CAPG (MCP) knockout HeLa cell lysate.
Human CAPG (MCP) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human HSPA8 (Hsc70) knockout HeLa cell lysate.
Human HSPA8 (Hsc70) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human PIK3R1 (PI 3 Kinase p85 alpha) knockout HeLa cell lysate.
Human PIK3R1 (PI 3 Kinase p85 alpha) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement